122 research outputs found
Diffusion maps embedding and transition matrix analysis of the large-scale flow structure in turbulent Rayleigh--B\'enard convection
By utilizing diffusion maps embedding and transition matrix analysis we
investigate sparse temperature measurement time-series data from
Rayleigh--B\'enard convection experiments in a cylindrical container of aspect
ratio between its diameter () and height (). We consider
the two cases of a cylinder at rest and rotating around its cylinder axis. We
find that the relative amplitude of the large-scale circulation (LSC) and its
orientation inside the container at different points in time are associated to
prominent geometric features in the embedding space spanned by the two dominant
diffusion-maps eigenvectors. From this two-dimensional embedding we can measure
azimuthal drift and diffusion rates, as well as coherence times of the LSC. In
addition, we can distinguish from the data clearly the single roll state (SRS),
when a single roll extends through the whole cell, from the double roll state
(DRS), when two counter-rotating rolls are on top of each other. Based on this
embedding we also build a transition matrix (a discrete transfer operator),
whose eigenvectors and eigenvalues reveal typical time scales for the stability
of the SRS and DRS as well as for the azimuthal drift velocity of the flow
structures inside the cylinder. Thus, the combination of nonlinear dimension
reduction and dynamical systems tools enables to gain insight into turbulent
flows without relying on model assumptions
Pseudo generators of spatial transfer operators
Metastable behavior in dynamical systems may be a significant challenge for a
simulation based analysis. In recent years, transfer operator based approaches
to problems exhibiting metastability have matured. In order to make these
approaches computationally feasible for larger systems, various reduction
techniques have been proposed: For example, Sch\"utte introduced a spatial
transfer operator which acts on densities on configuration space, while Weber
proposed to avoid trajectory simulation (like Froyland et al.) by considering a
discrete generator.
In this manuscript, we show that even though the family of spatial transfer
operators is not a semigroup, it possesses a well defined generating structure.
What is more, the pseudo generators up to order 4 in the Taylor expansion of
this family have particularly simple, explicit expressions involving no
momentum averaging. This makes collocation methods particularly easy to
implement and computationally efficient, which in turn may open the door for
further efficiency improvements in, e.g., the computational treatment of
conformation dynamics. We experimentally verify the predicted properties of
these pseudo generators by means of two academic examples
From large deviations to semidistances of transport and mixing: coherence analysis for finite Lagrangian data
One way to analyze complicated non-autonomous flows is through trying to
understand their transport behavior. In a quantitative, set-oriented approach
to transport and mixing, finite time coherent sets play an important role.
These are time-parametrized families of sets with unlikely transport to and
from their surroundings under small or vanishing random perturbations of the
dynamics. Here we propose, as a measure of transport and mixing for purely
advective (i.e., deterministic) flows, (semi)distances that arise under
vanishing perturbations in the sense of large deviations. Analogously, for
given finite Lagrangian trajectory data we derive a discrete-time and space
semidistance that comes from the "best" approximation of the randomly perturbed
process conditioned on this limited information of the deterministic flow. It
can be computed as shortest path in a graph with time-dependent weights.
Furthermore, we argue that coherent sets are regions of maximal farness in
terms of transport and mixing, hence they occur as extremal regions on a
spanning structure of the state space under this semidistance---in fact, under
any distance measure arising from the physical notion of transport. Based on
this notion we develop a tool to analyze the state space (or the finite
trajectory data at hand) and identify coherent regions. We validate our
approach on idealized prototypical examples and well-studied standard cases.Comment: J Nonlinear Sci, 201
Expression of multidrug resistance membrane transporter (Pgp) and p53 protein in canine mammary tumours
The aim of this study was to determine the expression rate of P-glycoprotein (Pgp), a multidrug resistance marker and the p53 tumour-suppressor protein in canine mammary tumours. A total of 30 tumours were examined in parallel to patient history. The tumours were allotted to four groups: tubulopapillar carcinomas, complex carcinomas, benign tumours, and other malignant tumours. A monoclonal mouse antibody (C494) was used for the immunohistochemical evaluation of Pgp and a polyclonal rabbit antibody for p53. We found that the intact ductal epithelium and connective tissue showed pronounced Pgp expression. The most intensive staining was detected in tubulopapillar carcinomas for both Pgp and p53. The expression rate of Pgp and p53 differed significantly between tubulopapillar carcinoma and complex carcinoma, and between tubulopapillar carcinoma and benign mammary tumour, respectively. The expressions of Pgp and p53 highly correlated statistically; therefore, both can determine malignancy in a similar manner. In the case of tubulopapillar carcinomas, more relapsed tumours occurred than in relation to complex carcinomas and other malignant tumours. Pgp expression rate was proportional to the probability of the tumour becoming recidivant postoperatively, as well. These results suggest that routine evaluation of Pgp expression in canine mammary tumours may be prognostically helpful
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